Compartmentalization of TNF Receptor 1 Signaling

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.

The molecular regulation of the recruitment of initial signaling complexes at the TNF-R1 is poorly defined. We demonstrate here that within minutes internalized TNF-R1 (TNF receptosomes) recruits TRADD, FADD, and caspase-8 to establish the "death-inducing signaling complex" (DISC). In addition, we identified the TNF-R1 internalization domain (TRID) required for receptor endocytosis and provide ...

Cardiac glycosides inhibit TNF- NF- B signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor

*Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; †Cancer and Cell Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and §Protein Expression Laboratory, National Cancer Institute SAIC, Nationa...

Histamine antagonizes TNF signaling 1 Histamine antagonizes TNF signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool

Suppression of TNF receptor-1 signaling in an in vitro model of epileptic tolerance.

Tumor necrosis factor-α (TNFα) is a pleiotropic cytokine that can regulate cell survival, inflammation or, under certain circumstances, trigger cell death. Previous work in rat seizure models and analysis of temporal lobe samples from epilepsy patients has suggested seizures activate TNF receptor 1 (TNFR1). Here we explored the activation and functional significance of TNFR1 signaling in the mo...

Induction of Jak/STAT signaling by activation of the type 1 TNF receptor.

Cellular responses to TNF are initiated by either of two cell surface receptors, the type 1 TNF receptor (TNFR1) and the type 2 TNF receptor (TNFR2). Although neither receptor contains an intrinsic protein tyrosine kinase, such activity has been implicated in TNF action. In this study, we show that murine TNF induces the tyrosine phosphorylation and activation of the intracellular Janus tyrosin...